Explore a collection of publications produced by Michigan Tech's Health Research Institute below.

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Submissions from 2024

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Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride, A. Apostle and S. Fang

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A Review on Machine Learning for Arterial Extraction and Quantitative Assessment on Invasive Coronary Angiograms, Pukar Baral, Chen Zhao, Michele Esposito, and Weihua Zhou

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Low Shear in Short-Term Impacts Endothelial Cell Traction and Alignment in Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, and Sangyoon J. Han

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Transient Low Shear Stress Preconditioning Influences Long-term Endothelial Traction and Alignment under High Shear Flow, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Etienne Michels, Samuel E. Haarman, Scott A. Severance, Yeonwoo Rho, and Sangyoon J. Han

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Low Shear in Short-Term Impacts Endothelial Cell Traction and Alignment in Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, and Sangyoon J. Han

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Induction of Neuroinflammation and Brain Oxidative Stress by Brain-Derived Extracellular Vesicles from Hypertensive Rats, Xinqian Chen, Xin Yan, Leah Gingerich, Qing Hui Chen, Lanrong Bi, and Zhiying Shan

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Near-infrared absorption and emission probes with optimal connection bridges for live monitoring of NAD(P)H dynamics in living systems, Sushil K. Dwivedi, Dilka Liyana Arachchige, May Waters, Sophia Jaeger, Mohamed Mahmoud, Adenike Olowolagba, Daniel R. Tucker, Micaela Rayne Geborkoff, Thomas Werner, Rudy Luck, Bhaskar Godugu, and Haiying Liu

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Oligodeoxynucleotide Synthesis Under Non-Nucleophilic Deprotection Conditions, Shiyue Fang, Komal Chillar, Yipeng Yin, Alexander Apostle, Dhananjani Eriyagama, Shahien Shahsavari, Bhaskar Halami, and Yinan Yuan

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Structural Changes Likely Cause Chemical Differences between Empty and Full AAV Capsids, Caryn Heldt, Molly A. Skinner, and Ganesh S. Anand

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3D Printing in the management of complex congenital heart disease, Jason E. Hernandez and Joseph Vettukattil

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Enhancing Cardiomyocyte Resilience to Ischemia-Reperfusion Injury: The Therapeutic Potential of an Indole-Peptide-Tempo Conjugate (IPTC), Shanshan Hou, Xin Yan, Xiang Gao, Steffen Jockusch, K. Michael Gibson, Zhiying Shan, and Lanrong Bi

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Automatic segmentation of intraluminal thrombosis of abdominal aortic aneurysms from CT angiography using a mixed-scale-driven multiview perception network (M2Net) model, Zonghan Lyu, Nan Mu, Mostafa Rezaeitaleshmahalleh, Xiaoming Zhang, Robert McBane, and Jingfeng Jiang

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Myosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin, Nikhil Mittal, Etienne B. Michels, Andrew E. Massey, Yunxiu Qiu, Shaina P. Royer-Weeden, Bryan R. Smith, Alexander X. Cartagena-Rivera, and Sangyoon J. Han

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Editorial: Mitral valve disease: mechanisms to therapies, Maria Carmo Nunes, Hoda Hatoum, Alison M. Pouch, and Muralidhar Padala

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Integrating Cardiovascular Engineering and Biofluid Mechanics in High School STEM Education: An Experiential Approach, Magen Radke, Fatiesa Sulejmani, Brennan Vogl, and Hoda Hatoum

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A staged approach using machine learning and uncertainty quantification to predict the risk of hip fracture, Anjum Shaik, Kristoffer A. Larsen, Nancy E. Lane, Chen Zhao, Kuan Jui Su, Joyce H. Keyak, Qing Tian, Qiuying Sha, Hui Shen, Hong Wen Deng, and Weihua Zhou

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Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion, Brennan Vogl, Emily Vitale, Sunyoung Ahn, Agata Sularz, Alejandra Chavez Ponce, Gerardo V. Lo Russo, Jeremy Collins, Alessandra Maria Bavo, Ahmed El Shaer, Anders Kramer, Yuheng Jia, Davorka Lulic, Matthieu De Beule, Jens Erik Nielsen-Kudsk, Ole De Backer, Mohamad Alkhouli, and Hoda Hatoum

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Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

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Multi-scale variational autoencoder for imputation of missing values in untargeted metabolomics using whole-genome sequencing data, Chen Zhao, Kuan-Jui Su, Chong Wu, Xuewei Cao, Qiuying Sha, Wu Li, Zhe Luo, Tian Qing, Chuan Qiu, Lan Juan Zhao, Anqi Liu, Lindong Jiang, Xiao Zhang, Hui Shen, Weihua Zhou, and Hong-Wen Deng

Works from 2023

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Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS-CoV-2 Replication Complex**, Alexander Apostle, Yipeng Yin, Komal Chillar, Adikari M.D.N. Eriyagama, Reed Arneson, Emma Burke, Shiyue Fang, and Yinan Yuan

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Highly Sensitive Cyanine Dyes for Rapid Sensing of NAD(P)H in Mitochondria and First-Instar Larvae of Drosophila melanogaster, Dilka Liyana Arachchige, Sushil K. Dwivedi, Sophia Jaeger, Adenike Olowolagba, Mohamed Mahmoud, Daniel R. Tucker, Delaney Fritz, Thomas Werner, Marina Tanasova, Rudy Luck, and Haiying Liu

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Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors, Dilka Liyana Arachchige, Sushil K. Dwivedi, May Waters, Sophia Jaeger, Joe Peters, Daniel R. Tucker, Micaela Rayne Geborkoff, Thomas Werner, Rudy Luck, Bhaskar Godugu, and Haiying Liu

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Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors, Dilka Liyana Arachchige, Sushil K. Dwivedi, May Waters, Sophia Jaeger, Joe Peters, Daniel R. Tucker, Micaela Rayne Geborkoff, Thomas Werner, Rudy Luck, Bhaskar Godugu, and Haiying Liu

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Effect of Beta Blockers on the Hemodynamics and Thrombotic Risk of Coronary Artery Aneurysms in Kawasaki Disease, Alireza Asadbeygi, Simon Lee, John Kovalchin, and Hoda Hatoum

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Conductive 3D nano-biohybrid systems based on densified carbon nanotube forests and living cells, Roya Bagheri, Alicia K. Ball, Masoud Kasraie, Aparna Chandra, Xinqian Chen, Ibrahim Miskioglu, Zhiying Shan, and Parisa Pour Shahid Saeed Abadi

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Oligonucleotide synthesis under mild deprotection conditions, Komal Chillar, Adikari M.D.N. Eriyagama, Yipeng Yin, Shahien Shahsavari, Bhaskar Halami, Alexander Apostle, and Shiyue Fang

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PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis, Komal Chillar, Yipeng Yin, Alexander Apostle, and Shiyue Fang

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Physiological and perceptual responses to acute arm cranking with blood flow restriction, Benjamin Cockfield, Isaac J. Wedig, Alyssa L. Vinckier, John McDaniel, and Steve Elmer

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Mechanism of multivalent glycoconjugate-lectin interaction: An update, Tarun K. Dam, Olivia Hohman, Lucas Sheppard, C. Fred Brewer, and Purnima Bandyopadhyay

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Mechanical Properties and Morphological Alterations in Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes, James Dolgin, Samerender Nagam Hanumantharao, Stephen Farias, Carl G. Simon, and Smitha Rao

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Thiophene-based organic dye with large Stokes shift and deep red emission for live cell NAD(P)H detection under varying chemical stimuli, Sushil K. Dwivedi, Dilka Liyana Arachchige, Adenike Olowolagba, Mohamed Mahmoud, Jenna Cunnien, Daniel R. Tucker, Delaney Fritz, Thomas Werner, Rudy L. Luck, and Haiying Liu

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Near-infrared rhodol dyes bearing salicylaldehyde moieties for ratiometric pH sensing in live cells during mitophagy and under hypoxia conditions, Sushil K. Dwivedi, Dilka Liyana Arachchige, Tara Vohs, Jiani Tang, Kyle Usimaki, Adenike Olowolagba, Delaney Raine Fritz, Rudy Luck, Thomas Werner, and Haiying Liu

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Reply to Surapaneni, Steve Elmer, Cassandra R. Gohn, John J. Durocher, and Naveen Sharma

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The impact of local blood residence time in neo-sinus on post transcatheter aortic valve replacement subclinical leaflet thrombosis-a commentary., Fateme Esmailie, Hoda Hatoum, Vinod H Thourani, and Lakshmi Prasad Dasi

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10th Annual Michigan Physiological Society Meeting: June 26-27, 2023, Brianna D. Harfmann, Steven Elmer, Jennifer R. Vranish, Subha Bhaskaran, John F. Zubek, Kevin Gordish, Andrew Butcko, Christopher M. Westercamp, Harold J. Bell, and Naveen Sharma

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Empty and Full AAV Capsid Charge and Hydrophobicity Differences Measured with Single-Particle AFM, Caryn L. Heidt, Oluwatoyin Areo, Pratik U. Joshi, Xue Mi, Yulia Ivanova, and Alex Berrill

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Design Rules for the Sequestration of Viruses into Polypeptide Complex Coacervates, Pratik U. Joshi, Claire Decker, Xianci Zeng, Arvind Sathyavageeswaran, Sarah L. Perry, and Caryn L. Heidt

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Multimodal peptide ligand extracts parvovirus from interface in affinity aqueous two-phase system, Pratik U. Joshi, Stephanie M. Kroger, Silviya P. Zustiak, and Caryn L. Heidt

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Deep-learning-based Image Segmentation for Image-based Computational Hemodynamic Analysis of Abdominal Aortic Aneurysms: A Comparison Study, Zonghan Lyu, Kristin King, Mostafa Rezaeitaleshmahalleh, Drew Pienta, Nan Mu, Chen Zhao, Weihua Zhou, and Jingfeng Jiang

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Automatic extraction of coronary arteries using deep learning in invasive coronary angiograms, Yinghui Meng, Zhenglong Du, Chen Zhao, Minghao Dong, Drew Pienta, Jinshan Tang, and Weihua Zhou

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S-Net: a multiple cross aggregation convolutional architecture for automatic segmentation of small/thin structures for cardiovascular applications, Nan Mu, Zonghan Lyu, Mostafa Rezaeitaleshmahalleh, Cassie Bonifas, Jordan Gosnell, Marcus Haw, Joseph Vettukattil, and Jingfeng Jiang

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An attention residual u-net with differential preprocessing and geometric postprocessing: Learning how to segment vasculature including intracranial aneurysms, Nan Mu, Zonghan Lyu, Mostafa Rezaeitaleshmahalleh, Jinshan Tang, and Jingfeng Jiang

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Exploring a frequency-domain attention-guided cascade U-Net: Towards spatially tunable segmentation of vasculature, Nan Mu, Zonghan Lyu, Xiaoming Zhang, Robert McBane, Aditya S. Pandey, and Jingfeng Jiang

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Turn-on Rhodamine Glycoconjugates Enable Real-Time GLUT Activity Monitoring in Live Cells and In Vivo, Monica M.S. Nyansa, Adelina Oronova, Nazar Gora, Micaela Rayne Geborkoff, Nathan Ostlund, Delaney Fritz, Thomas Werner, and Marina Tanasova

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Characterization of small abdominal aortic aneurysms' growth status using spatial pattern analysis of aneurismal hemodynamics, Mostafa Rezaeitaleshmahalleh, Zonghan Lyu, Nan Mu, Xiaoming Zhang, Todd E. Rasmussen, Robert D. McBane, and Jingfeng Jiang

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Radiomic-based Textural Analysis of Intraluminal Thrombus in Aortic Abdominal Aneurysms: A Demonstration of Automated Workflow, Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Weihua Zhou, Xiaoming Zhang, Todd E. Rasmussen, Robert D. McBane, and Jingfeng Jiang

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Computerized Differentiation of Growth Status for Abdominal Aortic Aneurysms: A Feasibility Study, Mostafa Rezaeitaleshmahalleh, Kevin Sunderland, Zonghan Lyu, Tonie Johnson, Kristin King, David A. Liedl, Janet M. Hofer, Min Wang, Xiaoming Zhang, Wiktoria Kuczmik, Todd E. Rasmussen, Robert D. McBane, and Jingfeng Jiang

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Differential Impact of Blood Pressure Control Targets on Epicardial Coronary Flow After Transcatheter Aortic Valve Replacement, Brennan Vogl, Alejandra Chavez-Ponce, Adam Wentworth, Eric Erie, Pradeep Yadav, Vinod H. Thourani, Lakshmi Prasad Dasi, Brian Lindman, Mohamad Alkhouli, and Hoda Hatoum

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Effect of aortic curvature on bioprosthetic aortic valve performance, Brennan Vogl, Rajat Gadhave, Zhenyu Wang, Ahmed El Shaer, Alejandra Chavez Ponce, Mohamad Alkhouli, and Hoda Hatoum

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Effect of Blood Pressure Levels on Sinus Hemodynamics in Relation to Calcification After Bioprosthetic Aortic Valve Replacement, Brennan Vogl, Agata Sularz, Scott Lilly, Vinod H. Thourani, Brian R. Lindman, Mohamad Alkhouli, and Hoda Hatoum

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Blood flow restriction as a potential therapy to restore physical function following COVID-19 infection, Isaac J. Wedig, John J. Durocher, John McDaniel, and Steve Elmer

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Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

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Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

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Long oligodeoxynucleotides: chemical synthesis, isolation via catching-by-polymerization, verification via sequencing, and gene expression demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, and Shiyue Fang

Works from 2022

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Determining independence and associations among various cardiovascular disease risk factors in 9-12 years old school-children: a cross sectional study, Abdulrahman I. Alaqil, Erich Petushek, Yuba R. Gautam, Karin A. Pfeiffer, and Joseph J. Carlson

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Dissolve-spin: Desalting oligonucleotides for MALDI MS analysis, Alexander Apostle and Shiyue Fang

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Mechanism of Mucin Recognition by Lectins: A Thermodynamic Study, Tarun K. Dam, Jared Edwards, Priyanka Dipak Kadav, and C. Fred Brewer

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Revealing the Identity of Human Galectin-3 as a Glycosaminoglycan-Binding Protein, Jared L. Edwards, Priyanka Dipak Kadav, Purnima Bandyopadhyay, and Tarun K. Dam

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Automated stepwise PEG synthesis using a base-labile protecting group, Dhananjani Eriyagama, Yipeng Yin, and Shiyue Fang

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Influence of an acute fast on ambulatory blood pressure and autonomic cardiovascular control, Joshua Eric Gonzalez and William H. Cooke

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Rapid Detection and Purification of Galectin-3 by the Capture and Release (CaRe) Method, Priyanka Dipak Kadav, Jared Edwards, Jessica Krycia, Purnima Bandyopadhyay, and Tarun K. Dam

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Quantitative analysis of the impact of disorder on the structural and electrical properties of polymer fibers, R. A. Makin, S. N. Hanumantharao, S. Rao, and S. M. Durbin

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Prophylaxis and Remediation for Future Pandemic Pathogens-(Lessons from a Post-COVID World), Mark E. Obrenovich, Moncef B. Tayahi, Caryn L. Heidt, and Steven N. Emancipator

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Late-Stage Functionalization through Click Chemistry Provides GLUT5-Targeting Glycoconjugate as a Potential PET Imaging Probe, Adelina Oronova and Marina Tanasova

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A Preliminary Study on the Usage of a Data-Driven Probabilistic Approach to Predict Valve Performance Under Different Physiological Conditions, Brennan Vogl, Yousef M. Darestani, Juan A. Crestanello, Brian R. Lindman, Mohamad A. Alkhouli, and Hoda Hatoum

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Post-Exercise Arterial Stiffness Responses Are Similar After Acute Eccentric and Concentric Arm Cycling, Travis Wakeham, Dakota J. Anderson, Steven J. Elmer, and John J. Durocher

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In-vitro cell culture model to determine toxic effects of soil Arsenic due to direct dermal exposure, Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, and Smitha Rao

Works from 2021

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Single-particle characterization of SARS-CoV-2 isoelectric point and comparison to variants of interest, Oluwatoyin Areo, Pratik U. Joshi, Mark Obrenovich, Moncef Tayahi, and Caryn L. Heldt

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8th Annual Michigan Physiological Society Meeting: June 24-25, 2021, Steve Elmer, Jennifer R. Vranish, Brianna D. Harfmann, Naveen Sharma, John J. Durocher, M Beth Zimmer, and Harold J. Bell

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Activation of Orexin System Stimulates CaMKII Expression, Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, and Zhiying Shan

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Controlled breathing and autonomic rhythms: Influence of auditory versus visual cues, Joshua Gonzalez, Stephanie R. Jewell, Steven Stelly, and William H. Cooke

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Additive manufacturing of conductive and high-strength epoxy-nanoclay-carbon nanotube composites, Masoud Kasraie and Parisa Pour Shahid Saeed Abadi

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Progressive global perception and local polishing network for lung infection segmentation of COVID-19 CT images, Nan Mu, Hongyu Wang, Yu Zhang, Jingfeng Jiang, and Jinshan Tang

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Kiss goodbye to the ‘kissing knees’: no association between frontal plane inward knee motion and risk of future non-contact ACL injury in elite female athletes, Agnethe Nilstad, Erich Petushek, Kam Ming Mok, Roald Bahr, and Tron Krosshaug

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The effect of a brief, web-based animated video for improving comprehension and implementation feasibility for reducing anterior cruciate ligament injury: A three-arm randomized controlled trial, Erich Petushek, Anne Inger Mørtvedt, Brittany L. Nelson, and Mary C. Hamati

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Clinical impacts of scar reduction on gated myocardial perfusion SPECT after cardiac resynchronization therapy, Chi Yen Wang, Guang Uei Hung, Hsu Chung Lo, Shih Chuan Tsai, Zhuo He, Xinwei Zhang, Kuo Feng Chiang, Jiangang Zou, Weihua Zhou, Jin Long Huang, and Shih Ann Chen

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ST-V-Net: incorporating shape prior into convolutional neural networks for proximal femur segmentation, Chen Zhao, Joyce H. Keyak, Jinshan Tang, Tadashi S. Kaneko, Sundeep Khosla, Weihua Zhou, and et. al.

Works from 2020

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Thermostabilization of viruses via complex coacervation, Xue Mi, Whitney C. Blocher McTigue, Pratik Umesh Joshi, Mallory K. Bunker, Caryn L. Heldt, and Sarah L. Perry

Works from 2019

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A capture and release method based on noncovalent ligand cross-linking and facile filtration for purification of lectins and glycoproteins, Christina J Welch, Melanie Talaga, Priyanka Dipak Kadav, Jared Edwards, Purnima Bandyopadhyay, and Tarun K. Dam