A longitudinal analysis of morphological shape variation of spleen in patients with fontan surgery

Authors

Varatharajan Nainamalai, Michigan Technological UniversityFollow
Håvard Bjørke Jenssen, Oslo Universitetssykehus
Mostafa Rezaeitaleshmahalleh, Michigan Technological UniversityFollow
Djinaud Prophete, Michigan Technological UniversityFollow
Jordan Gosnell, Helen DeVos Children's Hospital
Sarah Khan, Helen DeVos Children's Hospital
Marcus Haw, Helen DeVos Children's Hospital
Jingfeng Jiang, Michigan Technological UniversityFollow
Joseph Vettukattil, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

7-21-2025

Department

Department of Biomedical Engineering; Joint Center of Biocomputing and Digital Health; Health Research Institute; Institute of Computing and Cybersystems

Abstract

Background: Splenic size serves as a surrogate biomarker for predicting portal vein hyper-tension and liver abnormalities in subjects with Fontan Associated Liver Disease (FALD). We analyze the long-term shape variation of the spleen in FALD subjects using morphological shape features of radiomic features. Methods: We used 154 (84 from computed tomography and 70 from magnetic resonance) image volumes obtained from 36 individuals who underwent stage 3 Fontan procedure and 145 computed tomography images from controls to assess splenomegaly. To understand the splenomegaly, thirteen shape features of the spleen over three 10-year intervals, and variations between controls and FALD subjects were analyzed. Results: The spleen enlargement was observed in all intervals of the post-surgery period. Also, a significant difference (level of significance α = 0.05, p < α) was observed between the morphological shape features of controls and the Fontan Associated Liver Disease subjects. Conclusion: Morphological shape features clearly distinguish between controls and subjects after Fontan stage 3 correction.

Publisher's Statement

/© 2025 The Authors. Published by Elsevier Ltd. Publisher’s version of record: https://doi.org/10.1016/j.imu.2025.101665

Publication Title

Informatics in Medicine Unlocked

Recommended Citation

Nainamalai, V., Jenssen, H., Rezaeitaleshmahalleh, M., Prophete, D., Gosnell, J., Khan, S., Haw, M., Jiang, J., & Vettukattil, J. (2025). A longitudinal analysis of morphological shape variation of spleen in patients with fontan surgery. Informatics in Medicine Unlocked, 57. http://doi.org/10.1016/j.imu.2025.101665
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/1908

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Version

Publisher's PDF