Document Type

Article

Publication Date

7-21-2025

Department

Department of Biomedical Engineering; Joint Center of Biocomputing and Digital Health; Health Research Institute; Institute of Computing and Cybersystems

Abstract

Background: Splenic size serves as a surrogate biomarker for predicting portal vein hyper-tension and liver abnormalities in subjects with Fontan Associated Liver Disease (FALD). We analyze the long-term shape variation of the spleen in FALD subjects using morphological shape features of radiomic features. Methods: We used 154 (84 from computed tomography and 70 from magnetic resonance) image volumes obtained from 36 individuals who underwent stage 3 Fontan procedure and 145 computed tomography images from controls to assess splenomegaly. To understand the splenomegaly, thirteen shape features of the spleen over three 10-year intervals, and variations between controls and FALD subjects were analyzed. Results: The spleen enlargement was observed in all intervals of the post-surgery period. Also, a significant difference (level of significance α = 0.05, p < α) was observed between the morphological shape features of controls and the Fontan Associated Liver Disease subjects. Conclusion: Morphological shape features clearly distinguish between controls and subjects after Fontan stage 3 correction.

Publisher's Statement

/© 2025 The Authors. Published by Elsevier Ltd. Publisher’s version of record: https://doi.org/10.1016/j.imu.2025.101665

Publication Title

Informatics in Medicine Unlocked

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Version

Publisher's PDF

Download

Share

COinS