Design, Synthesis, and Biological Evaluation of Novel Mitochondria-targeting Exosomes
Document Type
Article
Publication Date
7-4-2023
Department
Department of Chemistry; Health Research Institute; Department of Kinesiology and Integrative Physiology
Abstract
Mitochondrial dysfunction is implicated in both brain tumors and neurodegenerative diseases, leading to various cellular abnormalities that can promote tumor growth and resistance to thera-pies, as well as impaired energy production and compromised neuronal function. Developing targeted therapies aimed at restoring mitochondrial function and improving overall cellular health could potentially be a promising approach to treating these conditions. Brain-derived exosomes (BR-EVs) have emerged as potential drug delivery vessels for neurological conditions. Herein, we report a new method for creating mitochondria-targeting exosomes and test its application in vitro and in vivo.
Publication Title
bioRxiv : the preprint server for biology
Recommended Citation
Yan, X.,
Chen, X.,
Shan, Z.,
&
Bi, L.
(2023).
Design, Synthesis, and Biological Evaluation of Novel Mitochondria-targeting Exosomes.
bioRxiv : the preprint server for biology.
http://doi.org/10.1101/2023.07.04.547719
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/2135
Version
Preprint