Document Type
Article
Publication Date
12-11-2023
Department
Department of Chemistry; Health Research Institute; Department of Kinesiology and Integrative Physiology
Abstract
Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has demonstrated promise in initial tests with primary neuron cells and healthy rats. This promising development represents a significant step forward in treating these debilitating conditions.
Publication Title
ACS Omega
Recommended Citation
Yan, X.,
Chen, X.,
Shan, Z.,
&
Bi, L.
(2023).
Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells.
ACS Omega,
8(51), 48984-48993.
http://doi.org/10.1021/acsomega.3c06617
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/328
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
Copyright © 2023 The Authors. Published by American Chemical Society. Publisher’s version of record: