Pre-vascularization enhances therapeutic effects of human mesenchymal stem cell sheets in full thickness skin wound repair
Document Type
Article
Publication Date
1-1-2017
Department
Department of Biomedical Engineering
Abstract
Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process. We hypothesized that pre-vascularized hMSC sheets would further improve regeneration by providing more versatile angiogenic factors and pre-formed microvessels. In this work,
Publication Title
Theranostics
Recommended Citation
Chen, L.,
Xing, Q.,
Zhai, Q.,
Tahtinen, M.,
Zhou, F.,
Chen, L.,
Xu, Y.,
Qi, S.,
&
Zhao, F.
(2017).
Pre-vascularization enhances therapeutic effects of human mesenchymal stem cell sheets in full thickness skin wound repair.
Theranostics,
7(1), 117-131.
http://doi.org/10.7150/thno.17031
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/1290