Black bear parathyroid hormone and methods of using black bear parathyroid hormone

Inventors

Seth W. Donahue, Michigan Technological University

Files

Abstract

Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.

Patent Number

US 8,987,201 B2

Assignee

Michigan Technological University, Houghton, MI (US)

Application Number

13/514,362

Date Filed

6-7-2012

Certificate of Correction

No

Issue Date

3-24-2015

Disciplines

Engineering

Comments

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Recommended Citation

Donahue, Seth W., "Black bear parathyroid hormone and methods of using black bear parathyroid hormone" (2015). Michigan Tech Patents. 24.
https://digitalcommons.mtu.edu/patents/24