PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis
Document Type
Article
Publication Date
10-31-2023
Department
Department of Chemistry; Health Research Institute
Abstract
Sensitive oligodeoxynucleotides (ODNs) can be synthesized using Dmoc phosphoramidites, but only short ODNs were demonstrated. Here, we report the synthesis of much longer ODNs, which was made possible by the use of PEGylated Dmoc (pDmoc) phosphoramidites. The longer ODNs synthesized include those containing the sensitive 4acC epigenetic modification recently discovered in nature.
Publication Title
Organic and Biomolecular Chemistry
Recommended Citation
Chillar, K.,
Yin, Y.,
Apostle, A.,
&
Fang, S.
(2023).
PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis.
Organic and Biomolecular Chemistry(45).
http://doi.org/10.1039/d3ob01495a
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/283