Prognostic value of E-cadherin and β-catenin in triple-negative breast cancer
Document Type
Conference Proceeding
Publication Date
1-1-2016
Abstract
© American Society for Clinical Pathology, 2016. All rights reserved. Objectives: To analyze the expression of E-cadherin and β-catenin in triple-negative breast cancer (TNBC) to assess their prognostic significance. Methods: The expression of E-cadherin and β-catenin was examined semiquantitatively and correlated with other pathologic factors and survival outcomes. Results: Of 72 consecutive TNBCs, 56% showed reduced membranous expression of E-cadherin or β-catenin, with a strong correlation to each other. Of the clinicopathologic factors analyzed, tumor size and nodal status were significantly associated with overall survival and disease-specific survival, while the latter remained an independent factor by multivariate analysis. Reduced E-cadherin and β-catenin were both significantly associated with a poor overall survival and disease-specific survival by univariate and multivariate analyses. Conclusions: E-cadherin and β-catenin expression provides discriminative prognostic power independent of conventional pathologic factors, thus further reinforcing the important role of cell adhesion molecules in the process of tumor metastasis, especially in TNBC.
Publication Title
American Journal of Clinical Pathology
Recommended Citation
Shen, T.,
Zhang, K.,
Siegal, G.,
&
Wei, S.
(2016).
Prognostic value of E-cadherin and β-catenin in triple-negative breast cancer.
American Journal of Clinical Pathology,
146(5), 603-610.
http://doi.org/10.1093/AJCP/AQW183
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/9768