Velocity scaling for optimizing replica exchange molecular dynamics

Document Type

Article

Publication Date

1-28-2011

Abstract

We discuss the use of velocity rescaling for generating rejection-free exchange moves in replica exchange molecular dynamics. We test the efficiency of this approach for a common test case, the trp-cage protein. Advantages and limitations of the approach are discussed and possible extensions outlined. © 2011 American Institute of Physics.

Publication Title

Journal of Chemical Physics

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