Structure-function relationships in KDM7 histone demethylases.
Document Type
Article
Publication Date
2019
Department
Department of Chemistry
Abstract
The demethylation of lysine residues of histone proteins is a key epigenetic mechanism in cells. The enzymes that catalyze these processes are called histone demethylases (KDMs). The largest family of KDMs is the Jumonji C (JmjC) domain-containing enzymes; these includes KDM2-7 subfamily of enzymes. The JmjC proteins are Fe(II) and 2-Oxoglutarate (2OG) - dependent dioxygenases that couple substrate oxidation to decarboxylation of 2OG to form succinate and CO
Publication Title
Adv Protein Chem Struct Biol
Recommended Citation
Chaturvedi, S.,
Ramanan, R.,
Waheed, S.,
Karabencheva-Christova, T.,
&
Christov, C.
(2019).
Structure-function relationships in KDM7 histone demethylases..
Adv Protein Chem Struct Biol,
117, 113-125.
http://doi.org/10.1016/bs.apcsb.2019.08.005
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/846
Publisher's Statement
Copyright © 2019 Elsevier Inc. All rights reserved. Publisher’s version of record: https://doi.org/10.1016/bs.apcsb.2019.08.005