Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking
Document Type
Article
Publication Date
1-1-2015
Abstract
We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and characterization of lysosome-dependent apoptosis. LysoProbes are superior to commercially available lysosome markers since the fluorescent signals are both stable and highly selective, and they will aid in characterization of lysosome morphology and trafficking. We predict that labeling of cancer cells and solid tumor tissues with LysoProbes will provide an important new tool for monitoring the role of lysosome trafficking in cancer invasion and metastasis.
Publication Title
Scientific Reports
Recommended Citation
Yapici, N.,
Bi, Y.,
Li, P.,
Chen, X.,
Yan, X.,
Mandalapu, S.,
Faucett, M.,
Jockusch, S.,
Ju, J.,
Gibson, K.,
Pavan, W.,
&
Bi, L.
(2015).
Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking.
Scientific Reports,
5.
http://doi.org/10.1038/srep08576
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8459