Purification of synthetic peptides using a catching full-length sequence by polymerization approach
Document Type
Article
Publication Date
3-7-2014
Department
Department of Chemistry
Abstract
During automated solid-phase peptide synthesis, failure sequences were capped with acetic anhydride. After synthesis, a polymerizable methacrylamide tag was attached to the full-length sequences. Peptide purification was then achieved by polymerizing the full-length sequences, washing away impurities, and cleaving the peptide product from the polymer
Publication Title
Organic Letters
Recommended Citation
Zhang, M.,
Pokharel, D.,
&
Fang, S.
(2014).
Purification of synthetic peptides using a catching full-length sequence by polymerization approach.
Organic Letters,
16(5), 1290-1293.
http://doi.org/10.1021/ol403426u
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8198