Title

New rhodamine nitroxide based fluorescent probes for intracellular hydroxyl radical identification in living cells

Document Type

Article

Publication Date

1-6-2012

Abstract

The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate •OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for •OH detection. © 2011 American Chemical Society.

Publication Title

Organic Letters

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