Novel TEMPO-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion
Document Type
Article
Publication Date
5-10-2012
Abstract
We have recently developed new Tempo-PEG-RGDs conjugates and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion. Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage. © 2012 American Chemical Society.
Publication Title
Journal of Medicinal Chemistry
Recommended Citation
Bi, W.,
Li, X.,
Bi, Y.,
Xue, P.,
Zhang, Y.,
Gao, X.,
Wang, Z.,
Li, M.,
Itagaki, Y.,
&
Bi, L.
(2012).
Novel TEMPO-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion.
Journal of Medicinal Chemistry,
55(9), 4501-4505.
http://doi.org/10.1021/jm201381w
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8053