Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Document Type
Article
Publication Date
9-23-2010
Abstract
To develop more potent therapeutic agents with therapeutic efficacy for ischemia/reperfusion (I/R) injury, we linked an antiinflammatory moiety (1,3-dioxane derivative) to the key pharmacophoric moiety of melatonin. We hypothesized that the resulting new indole derivatives might induce a synergistic protection against oxidative damage associated with I/R injury. Our results indicate that one of these indole derivatives (7) manifests potent antiinflammatory antioxidant effects and exerts a protective effect against skeletal muscle injury and associated lung injury following limb I/R in rats. © 2010 American Chemical Society.
Publication Title
Journal of Medicinal Chemistry
Recommended Citation
Bi, W.,
Bi, Y.,
Xue, P.,
Zhang, Y.,
Gao, X.,
Wang, Z.,
Li, M.,
Baudy-Floch, M.,
Ngerebara, N.,
Gibson, K.,
&
Bi, L.
(2010).
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury.
Journal of Medicinal Chemistry,
53(18), 6763-6767.
http://doi.org/10.1021/jm100529e
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8052