Synthesis of ϵ-Rhodomycinone Glycosides

Document Type

Article

Publication Date

7-1-1977

Abstract

Twenty-six ϵ-rhodomycinone glycosides have been synthesized. These include the ϵ-rhodomycinone glycosides of 2-deoxy-L-fucose, 2-deoxy-L-rhamnose, and 2-deoxy-D-ribose as well as their 2-hydroxyl derivatives. NMR spectroscopy showed that all the glycosides prepared had the saccharide residues linked to position 10 of ϵ-rhodomycinone and helped establish the anomeric purity and configuration of several glycosides. Preliminary screening results show that 2-deoxy-di-O-acetyl-D-ribopyranosyl-ϵ-rhodomycinone has an activity T/C of 125 on P388 tumors. © 1977, American Chemical Society. All rights reserved.

Publication Title

Journal of Medicinal Chemistry

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