Parallel, Large-Scale, and Long Synthetic Oligodeoxynucleotide Purification Using the Catching Full-Length Sequence by Polymerization Technique
Document Type
Article
Publication Date
9-21-2018
Abstract
© 2018 American Chemical Society. The catching by polymerization synthetic oligodeoxynucleotide (ODN) purification technique was shown to be potentially suitable for high-throughput purification by the purification of 12 ODNs simultaneously, to be convenient for large-scale purification by purification at the 60 μmol synthesis scale, and to be highly powerful for purification of long ODNs by purification of ODNs as long as 303-mers. LC-MS analysis indicated that the ODNs purified with the technique have excellent purity.
Publication Title
Organic Process Research and Development
Recommended Citation
Eriyagama, D.,
Shahsavari, S.,
Halami, B.,
Lu, B.,
Wei, F.,
&
Fang, S.
(2018).
Parallel, Large-Scale, and Long Synthetic Oligodeoxynucleotide Purification Using the Catching Full-Length Sequence by Polymerization Technique.
Organic Process Research and Development,
22(9), 1282-1288.
http://doi.org/10.1021/acs.oprd.8b00209
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7822