Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat
Document Type
Article
Publication Date
6-1-2011
Abstract
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.
Publication Title
European Journal of Medicinal Chemistry
Recommended Citation
Bi, W.,
Bi, Y.,
Xue, P.,
Zhang, Y.,
Gao, X.,
Wang, Z.,
Li, M.,
Baudy-Floc'H, M.,
Ngerebara, N.,
Li, X.,
Gibson, K.,
&
Bi, L.
(2011).
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
European Journal of Medicinal Chemistry,
46(6), 2441-2452.
http://doi.org/10.1016/j.ejmech.2011.03.029
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6318