A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury
Document Type
Article
Publication Date
5-2011
Department
Department of Biological Sciences; Department of Chemistry
Abstract
We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.
Publication Title
European Journal of Medicinal Chemistry
Recommended Citation
Bi, W.,
Bi, Y.,
Xue, P.,
Zhang, Y.,
Gao, X.,
Wang, Z.,
Li, M.,
Baudy-Floc'H, M.,
Ngerebara, N.,
Michael Gibson, K.,
&
Bi, L.
(2011).
A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury.
European Journal of Medicinal Chemistry,
46(5), 1453-1462.
http://doi.org/10.1016/j.ejmech.2011.01.021
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6317