Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury
Document Type
Article
Publication Date
8-15-2016
Department
Department of Chemistry
Abstract
We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
Publication Title
Bioorganic and Medicinal Chemistry Letters
Recommended Citation
Bi, W.,
Bi, Y.,
Gao, X.,
Yan, X.,
Zhang, Y.,
Harris, J.,
Legalley, T.,
Gibson, K.,
&
Bi, L.
(2016).
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.
Bioorganic and Medicinal Chemistry Letters,
26(16), 4042-4051.
http://doi.org/10.1016/j.bmcl.2016.06.079
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6057