Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules
Document Type
Article
Publication Date
4-15-2016
Department
Department of Chemistry
Abstract
Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function.
Publication Title
Bioorganic and Medicinal Chemistry Letters
Recommended Citation
Bi, W.,
Bi, Y.,
Gao, X.,
Yan, X.,
Zhang, Y.,
Xue, P.,
Bammert, C.,
Legalley, T.,
Michael Gibson, K.,
Bi, L.,
&
Wang, J.
(2016).
Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules.
Bioorganic and Medicinal Chemistry Letters,
26(8), 2005-2013.
http://doi.org/10.1016/j.bmcl.2016.02.086
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6056
