Polybromo-1: The chromatin targeting subunit of the PBAF complex
Document Type
Article
Publication Date
3-2009
Department
Department of Chemistry
Abstract
The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. Pb1 coordinates key features common to all remodeling complexes, including chromatin localization, recruitment of protein subunits and alteration of chromatin architecture. A comprehensive analysis of individual domains composing Pb1 is used to propose new information regarding the function of Pb1 in the PBAF chromatin-remodeling complex. The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer.
Publication Title
Biochimie
Recommended Citation
Thompson, M.
(2009).
Polybromo-1: The chromatin targeting subunit of the PBAF complex.
Biochimie,
91(3), 309-319.
http://doi.org/10.1016/j.biochi.2008.10.019
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6020