Phosphorous‐containing analogues of aspartame
Document Type
Article
Publication Date
1-1-1984
Department
Department of Chemistry; Department of Chemical Engineering
Abstract
Four analogues of aspartame (aspartylphenylalanine methyl ester) were prepared in which one of the carboxylate groups was replaced by a phosphonate group. None of the peptides so obtained was sweet, in contrast with the parent compound which is over 100 times sweeter than sucrose. These results contrast with several published reports of phosphonate analogues of amino acids and peptides which are potent inhibitors of enzymes containing acceptor sites for the parent compound.
Publication Title
Journal of Pharmaceutical Sciences
Recommended Citation
Nelson, V.,
&
Mastalerz, P.
(1984).
Phosphorous‐containing analogues of aspartame.
Journal of Pharmaceutical Sciences,
73(12), 1844-1846.
http://doi.org/10.1002/jps.2600731252
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/3753
Publisher's Statement
Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company. Publisher’s version of record: https://doi.org/10.1002/jps.2600731252