Solvent-free solid acid-catalyzed electrophilic annelations: A new green approach for the synthesis of substituted five-membered N-heterocycles
Document Type
Article
Publication Date
10-2006
Department
Department of Chemistry
Abstract
An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75-98%) yields with practically 100% selectivity. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Publication Title
Advanced Synthesis and Catalysis
Recommended Citation
Abid, M.,
Spaeth, A.,
&
Török, B.
(2006).
Solvent-free solid acid-catalyzed electrophilic annelations: A new green approach for the synthesis of substituted five-membered N-heterocycles.
Advanced Synthesis and Catalysis,
348(15), 2191-2196.
http://doi.org/10.1002/adsc.200606200
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/3455