Benchtop proof of concept and comparison of iron- and magnesium-based bioresorbable flow diverters
Document Type
Article
Publication Date
7-2023
Department
Department of Biomedical Engineering
Abstract
OBJECTIVE: Bioresorbable flow diverters (BRFDs) could significantly improve the performance of next-generation flow diverter technology. In the current work, magnesium and iron alloy BRFDs were prototyped and compared in terms of porosity/pore density, radial strength, flow diversion functionality, and resorption kinetics to offer insights into selecting the best available bioresorbable metal candidate for the BRFD application. METHODS: BRFDs were constructed with braided wires made from alloys of magnesium (MgBRFD) or iron (FeBRFD). Pore density and crush resistance force were measured using established methods. BRFDs were deployed in silicone aneurysm models attached to flow loops to investigate flow diversion functionality and resorption kinetics in a simulated physiological environment. RESULTS: The FeBRFD exhibited higher pore density (9.9 vs 4.3 pores/mm2) and crush resistance force (0.69 ± 0.05 vs 0.53 ± 0.05 N/cm, p = 0.0765, n = 3 per group) than the MgBRFD, although both crush resistances were within the range previously reported for FDA-approved flow diverters. The FeBRFD demonstrated greater flow diversion functionality than the MgBRFD, with significantly higher values of established flow diversion metrics (mean transit time 159.6 ± 11.9 vs 110.9 ± 1.6, p = 0.015; inverse washout slope 192.5 ± 9.0 vs 116.5 ± 1.5, p = 0.001; n = 3 per group; both metrics expressed as a percentage of the control condition). Last, the FeBRFD was able to maintain its braided structure for > 12 weeks, whereas the MgBRFD was almost completely resorbed after 5 weeks. CONCLUSIONS: The results of this study demonstrated the ability to manufacture BRFDs with magnesium and iron alloys. The data suggest that the iron alloy is the superior material candidate for the BRFD application due to its higher mechanical strength and lower resorption rate relative to the magnesium alloy.
Publication Title
Journal of neurosurgery
Recommended Citation
Oliver, A.,
Bilgin, C.,
Vercnocke, A.,
Carlson, K.,
Kadirvel, R.,
Guillory, R. J.,
Griebel, A.,
Schaffer, J.,
Dragomir-Daescu, D.,
&
Kallmes, D.
(2023).
Benchtop proof of concept and comparison of iron- and magnesium-based bioresorbable flow diverters.
Journal of neurosurgery,
139(1), 150-156.
http://doi.org/10.3171/2022.11.JNS222213
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/17384