Document Type
Article
Publication Date
8-4-2022
Department
Department of Chemistry; Michigan Tech Research Institute
Abstract
Facilitative sugar transporters (GLUTs) are the primary method of sugar uptake in all mammalian cells. There are 14 different types of those transmembrane proteins, but they transport only a handful of substrates, mainly glucose and fructose. This overlap and redundancy contradict the natural tendency of cells to conserve energy and resources, and has led researchers to hypothesize that different GLUTs partake in more metabolic roles than just sugar transport into cells. Understanding those roles will lead to better therapeutics for a wide variety of diseases and disorders. In this review we highlight recent discoveries of the role GLUTs play in different diseases and disease treatments.
Publication Title
International journal of molecular sciences
Recommended Citation
Ismail, A.,
&
Tanasova, M.
(2022).
Importance of GLUT Transporters in Disease Diagnosis and Treatment.
International journal of molecular sciences,
23(15).
http://doi.org/10.3390/ijms23158698
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/16328
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Publisher’s version of record: https://doi.org/10.3390/ijms23158698