Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway
Document Type
Article
Publication Date
1-1-2014
Abstract
This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL- 6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence that ovarian cancer cells with a stimulated STAT 3 pathway have high survival rates and drug resistance. And we discussed how the IL6 and these well-known microscopic factors impacted the cancer progression. Copyright © 2014 Inderscience Enterprises Ltd.
Publication Title
International Journal of Data Mining and Bioinformatics
Recommended Citation
Zhang, L.,
Xue, Y.,
Jiang, B.,
Strouthos, C.,
Duan, Z.,
Wu, Y.,
Su, J.,
&
Zhou, X.
(2014).
Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway.
International Journal of Data Mining and Bioinformatics,
9(3), 235-253.
http://doi.org/10.1504/IJDMB.2014.060050
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/13418