Title

Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.

Document Type

Article

Publication Date

4-12-2018

Department

Department of Biological Sciences, Department of Chemistry

Abstract

The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.

Publication Title

Chemical Communications

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