Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.
Department of Biological Sciences; Department of Chemistry
The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.
Begoyan, V. V.,
Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis..
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