Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.
Document Type
Article
Publication Date
4-12-2018
Department
Department of Biological Sciences; Department of Chemistry
Abstract
The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.
Publication Title
Chemical Communications
Recommended Citation
Begoyan, V. V.,
Weseliński, Ł.,
Xia, S.,
Fedie, J.,
Kannan, S.,
Ferrier, A.,
Rao, S.,
&
Tanasova, M.
(2018).
Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis..
Chemical Communications,
54(31), 3855-3858.
http://doi.org/10.1039/C7CC09809J
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/1282