Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.

Authors

Vaho V. Begoyan, Michigan Technological UniversityFollow
Ł J Weseliński, Michigan Technological University
S. Xia, Michigan Technological University
Joseph Fedie, Michigan Technological UniversityFollow
S. Kannan, Michigan Technological University
A. Ferrier, Michigan Technological University
Smitha Rao, Michigan Technological UniversityFollow
Marina Tanasova, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

4-12-2018

Department

Department of Biological Sciences; Department of Chemistry

Abstract

The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.

Publication Title

Chemical Communications

Recommended Citation

Begoyan, V. V., Weseliński, Ł., Xia, S., Fedie, J., Kannan, S., Ferrier, A., Rao, S., & Tanasova, M. (2018). Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.. Chemical Communications, 54(31), 3855-3858. http://doi.org/10.1039/C7CC09809J
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/1282