Laser-guided direct writing: A novel method to deposit biomolecules for biosensors arrays
Document Type
Article
Publication Date
1-1-2003
Abstract
In this paper, we present a potential biomolecular patterning method, laser-guided direct writing guidance (LGDW), which may be utilized to deposit organic and bioactive particles for biosensor arrays. The instrumentation and operation of the LGDW system is introduced and the system settings used to achieve deposition are reported. The biomolecule, avidin, was deposited onto a substrate using LGDW to evaluate the possible damage from the laser on the biomolecules. The functionality of avidin after laser-based guidance was examined by exposing the deposited avidin molecules to its ligand, biotin. The results show some avidin retained its affinity to biotin after LGDW demonstrating little damage to the biomolecules.
Publication Title
IEEE Transactions on Biomedical Engineering
Recommended Citation
Xu, J.,
Grant, S.,
&
Pastel, R.
(2003).
Laser-guided direct writing: A novel method to deposit biomolecules for biosensors arrays.
IEEE Transactions on Biomedical Engineering,
50(1), 126-128.
http://doi.org/10.1109/TBME.2002.805461
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/10963