Energy landscape paving for X-ray structure determination of organic molecules

Document Type

Article

Publication Date

1-1-2002

Abstract

The efficiency of a recently proposed novel global optimization method, energy landscape paving (ELP), is evaluated with regard to the problem of crystal structure determination from simulated X-ray diffraction data comprising integrated diffraction intensities. The new approach has been tested using the example of 9-(methylamino)-1H-phenalen-1-one 1,4-dioxan-2-y1 hydroperoxide solvate (C14H11NO · C4H8O4). The results indicate that, for this example, ELP outperforms standard techniques such as simulated annealing. © 2002 International Union of Crystallography.

Publication Title

Acta Crystallographica Section A: Foundations of Crystallography

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