Short-time dynamics of the helix-coil transition in polypeptides
Document Type
Article
Publication Date
5-15-2006
Abstract
We study the critical relaxation of the helix-coil transition in all-atom models of polyalanine chains. We show that at the critical temperature the decay of a completely helical conformation can be described by scaling relations that allow us estimating the pertinent critical exponents. The present approach opens a new way for characterizing transitions in proteins and may lead to a better understanding of their folding mechanism. An application of the technique to the 34-residue human parathyroid fragment PTH(1-34) supports universality of the helix-coil transition in homopolymers and (helical) proteins. © 2006 The American Physical Society.
Publication Title
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Recommended Citation
Arashiro, E.,
Drugowich De Felício, J.,
&
Hansmann, U.
(2006).
Short-time dynamics of the helix-coil transition in polypeptides.
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics,
73(4).
http://doi.org/10.1103/PhysRevE.73.040902
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/10073