Studying mass and mechanical property changes during the degradation of a bioadhesive with mass tracking, rheology and magnetoelastic (ME) sensors

Author

Zhongtian Zhang, Michigan Technological UniversityFollow

Date of Award

2018

Document Type

Open Access Master's Thesis

Degree Name

Master of Science in Biomedical Engineering (MS)

Administrative Home Department

Department of Biomedical Engineering

Advisor 1

Bruce P. Lee

Advisor 2

Keat Ghee Ong

Committee Member 1

Rupak Rajachar

Committee Member 2

Faith A. Morrison

Abstract

In this research, the degradable polymer 4-arm poly (ethylene glycol)-glutaric acid-dopamine (PEG-GA-DM₄) was synthesized. The degradation behavior of crosslinked PEG-GA-DM₄ bioadhesive was studied with mass tracking, oscillatory rheology, and magnetoelastic (ME) sensors. Changes in mechanical properties were correlated with both dry mass and wet mass changes during the degradation. The results indicate that the loss of mechanical property in the bioadhesive can take place without losing the dry mass. The mass loss profile cannot describe the degradation behavior completely. In addition to studying the degradation of PEG-GA-DM₄, this research also confirms the application of ME sensors as a means to study the mechanical and degradation behavior of bioadhesive.

Recommended Citation

Zhang, Zhongtian, "Studying mass and mechanical property changes during the degradation of a bioadhesive with mass tracking, rheology and magnetoelastic (ME) sensors", Open Access Master's Thesis, Michigan Technological University, 2018.

https://doi.org/10.37099/mtu.dc.etdr/701