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Date of Award
2024
Document Type
Campus Access Dissertation
Degree Name
Doctor of Philosophy in Biomedical Engineering (PhD)
Administrative Home Department
Department of Biomedical Engineering
Advisor 1
Jeremy Goldman
Committee Member 1
Roger J. Guillory II
Committee Member 2
Jaroslaw Drelich
Committee Member 3
Chunxiu Yu
Abstract
Heart disease is the leading cause of death world-wide with coronary artery disease, or atherosclerosis, being the most common form of heart disease. To treat atherosclerosis, stenting is commonly used to widen or reopen narrowed arteries and restore proper blood flow to tissues. The industry standard stent is a bare-metal or drug-eluting stent. Both of these stent types are permanent and can have complications, including in-stent restenosis and thrombosis. Some of these complications would be reduced with bioresorbable stents. In this work, a possible bioresorbable Zn-Cu alloy for arterial stenting applications was investigated using a rodent wire implantation model.
In addition to needing different materials for stenting, the environment in which they are investigated needs to be taken into account. Most biocompatibility studies are done in young, healthy animals. However, the human patients they will be implanted in tend to be older and have comorbidities that could influence how the body responds. Therefore, two different animal models, of transgenic diseased mice and aged rats, were investigated for future material testing through wire implantation of pure platinum and zinc wires. In the diseased ApoE-/- mice, there was significantly more neointimal tissue growth, increased inflammation and smooth muscle cell (SMC) presence than healthy counterparts. In aged rats, there was a decrease in inflammation and SMC presence, but an increase in neointimal tissue area.
Recommended Citation
Morath, Lea M., "EFFECT OF BIO-ENVIRONMENT AND CU ALLOYING ON ZINC IMPLANT BIOCOMPATIBILITY", Campus Access Dissertation, Michigan Technological University, 2024.