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Date of Award
2023
Document Type
Campus Access Master's Report
Degree Name
Master of Science in Biological Sciences (MS)
Administrative Home Department
Department of Biological Sciences
Advisor 1
Marina Tanasova
Advisor 2
Smitha Rao
Committee Member 1
Rupali Datta
Abstract
Elevated sugar uptake and metabolism have long been recognized as hallmarks of cancer, laying the groundwork for a new understanding of the changes that occur during cancer development as well as new strategies to target and impact cancer cells. The Warburg effect, which refers to increased glucose uptake in cancer cells, has fueled numerous studies on the use of agents that target various receptors, transporters, and enzymes involved in glucose metabolism. Courmarin glycoconjugates were used as basis of fluorescent probes to assess activity of glucose transporters. Among those, the corresponding GLUT5-specific glycoconjugates were found to accumulate in GLUT5-positive cancer cells over short period of time and function as activity reporters. Here, we show that prolonged targeting of GLUT5 induced cytotoxic effect in GLUT5-positive cancers and can improve the cytotoxic outcomes of cisplatin in different cancer cell lines.
Recommended Citation
Buwa, Vedant, "Establishing the impact of GLUT5 targeting specific probes on cytotoxicity of cisplatin in cancer cells", Campus Access Master's Report, Michigan Technological University, 2023.
