Date of Award
2020
Document Type
Open Access Master's Report
Degree Name
Master of Science in Chemical Engineering (MS)
Administrative Home Department
Department of Chemical Engineering
Advisor 1
Caryn Heldt
Committee Member 1
Rebecca Ong
Committee Member 2
Timothy Eisele
Abstract
Influenza virus has an intrinsic nature to undergo mutations. Hence, there have been struggles to combat this disease since the time when the worst influenza pandemic first hit in 1918. Vaccines have proved to be effective in controlling the spread of the influenza A virus by providing herd immunity. However, the contemporary design of influenza A virus based on egg and cell-culture is not efficient in tackling influenza A virus transformation. Virus-like particles (VLPs) have established themselves as a potental platform for future vaccine candidates. VLPs have all the credentials to supplant contemporary vaccine designs without compromising on immunogenicity. For expression of VLPs, yeast has all the definitive potential to develop new-generation influenza A vaccines. This report describes how to use Hansenula polymorpha, a yeast, to make VLPs of influenza H1N1 virus.
Recommended Citation
Ananya, Ananya, "VIRUS-LIKE PARTICLE VACCINE MANUFACTURING FROM YEAST", Open Access Master's Report, Michigan Technological University, 2020.