Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging
Document Type
Article
Publication Date
10-31-2012
Abstract
Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to αvβ3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.
Publication Title
Analytica Chimica Acta
Recommended Citation
Zhu, S.,
Zhang, J.,
Janjanam, J.,
Bi, J.,
Vegesna, G.,
Tiwari, A.,
Luo, F.,
Wei, J.,
&
Liu, H.
(2012).
Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging.
Analytica Chimica Acta,
758, 138-144.
http://doi.org/10.1016/j.aca.2012.10.026
Retrieved from: https://digitalcommons.mtu.edu/chemistry-fp/114
Publisher's Statement
© 2012 Elsevier B.V. All rights reserved. Publisher's version of record: https://doi.org/10.1016/j.aca.2012.10.026