Title

Electrospun nanofibers as neural guidance scaffolds

Authors

Michael Mullins, Michigan Technological UniversityFollow

Files

Publication Date

12-1-2016

Description

Highly-aligned electrospun PolyLactic-L-Acid (PLLA) nanofibers have been shown to promote and direct the axonal outgrowth of Central Nervous System (CNS) neurons. Aligned fibers deposited on 3D printed stages have been tested in vitro using chick Dorsal Root Ganglia (DRG's), and show highly directed neurite growth with improved extension. In vivo studies on rats indicate that similar results are attained, with substantial regrowth of fully transected spinal cords. Extension of these studies to new generation of coaxial nanofiber scaffolds which allow electrical stimulation are in progress.

Disciplines

Chemical Engineering

Recommended Citation

Mullins, Michael, "Electrospun nanofibers as neural guidance scaffolds" (2016). TechTalks. 22.
https://digitalcommons.mtu.edu/techtalks/22