Isolation and nanoformulation of mucilage from Abelmoschus esculentus (okra) biomass and evaluation of its biological activities and biocompatibility

Document Type

Article

Publication Date

5-8-2024

Department

College of Computing

Abstract

Abstract: Mucilage derived from the various plant species has gained more attention in biomedicine field as its high potential bioactivities. However, the peer solubility and bioavailability limits the desired biological activities. Nanotechnology principles can be effectively utilized in the formulation of various plant-based products which enhance the desired activity. In this study, mucilage extracted from Abelmoschus esculentus (okra) was formulated as nanocomposite using biocompatible polymers such as polyvinyl alcohol (PVA) and polyethylene glycol (PEG) via simple, in-situ green technology principles. A simple dispersion technique was adapted for developing the nanocomposite, which had highly stable nanoscale core dense particles that were naturally crystalline. The developed nanocomposite exhibited notable antimicrobial activity against human pathogenic bacterial and fungal strains. They also recorded notable antioxidant activity. Biocompatibility was screened by phytotoxicity assessment and hemocompatibility assessment. Results expressed that the treatment of nanocomposite has not shown any impact on the seedlings and protein profile of groundnut seeds. Hemocompatibility study revealed that the nanocomposite has not shown undesirable effects on the peripheral blood cells. The present study suggests the possible abilities of mucilage-loaded nanocomposite as an effective bioactive agent. Graphical abstract: (Figure presented.)

Publication Title

Biomass Conversion and Biorefinery

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