Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Authors

Aline Alexandrina Gomes, Universidade Federal de Ouro Preto
Thalita Marcolan Valverde, Universidade Federal de Minas Gerais
Vagner de Oliveira Machado, Universidade Federal de Ouro Preto
Emanueli do Nascimento da Silva, Universidade Federal de Ouro Preto
Daniele Alves Fagundes, Center of Nuclear Technology Development, Belo Horizonte
Fernanda de Paula Oliveira, Center of Nuclear Technology Development, Belo Horizonte
Erico Freitas, Michigan Technological UniversityFollow
José Domingos Ardisson, Center of Nuclear Technology Development, Belo Horizonte
José Maria da Fonte Ferreira, CICECO – Instituto de Materiais de Aveiro
Junnia Alvarenga de Carvalho Oliveira, Universidade Federal de Minas Gerais
Eliza Rocha Gomes, Universidade Federal de Minas Gerais
Caio Fabrini Rodrigues, Universidade Federal de Minas Gerais
Alfredo Miranda de Goes, Universidade Federal de Minas Gerais
Rosana Zacarias Domingues, Universidade Federal de Minas Gerais
Ângela Leão Andrade, Universidade Federal de Ouro Preto

Document Type

Article

Publication Date

2024

Department

Department of Materials Science and Engineering

Abstract

Cancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid-co-trimethylene carbonate) and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 °C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.

Publisher's Statement

Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. Publisher’s version of record: https://doi.org/10.3390/ijms25010493

Publication Title

International Journal of Molecular Sciences

Recommended Citation

Gomes, A., Valverde, T., Machado, V., do Nascimento da Silva, E., Fagundes, D., Oliveira, F., Freitas, E., Ardisson, J., Ferreira, J., Oliveira, J., Gomes, E., Rodrigues, C., Goes, A., Domingues, R., & Andrade, Â. (2024). Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment. International Journal of Molecular Sciences, 25(1). http://doi.org/10.3390/ijms25010493
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/442

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Version

Publisher's PDF