Mechanics Post-TAVR for Trileaflet vs Bicuspid Aortic Valves: Insights from Computational Simulation
Document Type
Article
Publication Date
12-2025
Department
College of Engineering; Department of Biomedical Engineering
Abstract
Background: Bicuspid aortic valve (BAV) disease is the most common congenital heart defect and is associated with elliptical openings and excess calcification. Limited data are available on long-term efficacy of transcatheter aortic valve replacement (TAVR) for BAV patients.
Objectives: The purpose of this study was to compare simulated mechanical metrics post-TAVR between BAV and trileaflet patients with calcific aortic stenosis.
Methods: Pre-TAVR computed tomography scans of trileaflet (n = 22) and BAV (n = 25) were used to segment the aortic valve. Simulated balloon-expandable stent deployment was performed from a previously developed protocol. The bioprosthetic leaflets were then pressurized under a physiological pressure. Stent waist expansion ratio, aspect ratio (AR), leaflet systolic normalized geometric orifice area (GOA), and maximum leaflet diastolic stress were measured.
Results: BAVs had lower waist expansion ratio (87.8% ± 2.6% vs 89.4% ± 1.4%; P < 0.001), lower waist AR (94.6% ± 2.8% vs 98.2% ± 1.0%; P < 0.001), lower normalized GOA (88.9% ± 0.8% vs 89.5% ± 0.7%; P < 0.01), and higher maximum stress (2.81 ± 0.44 vs 2.29 ± 0.25 MPa; P < 0.001) on average compared to trileaflet patients, respectively. Within the BAV group, calcium volume was correlated with waist AR (r = −0.75, P < 0.001), normalized GOA (r = −0.68, P < 0.001), and maximum stress (r = 0.66, P < 0.001).
Conclusions: Balloon-expandable TAVR for BAV has worse simulated mechanical metrics compared to TAVR for trileaflet aortic valve patients and is associated with high calcium volume.
Publication Title
Jacc Advances
Recommended Citation
Yeats, B.,
Venkatesh, A.,
Sivakumar, S.,
Hatoum, H.,
Samaee, M.,
Polsani, V.,
&
et. al.
(2025).
Mechanics Post-TAVR for Trileaflet vs Bicuspid Aortic Valves: Insights from Computational Simulation.
Jacc Advances,
4(12P2), 102358.
http://doi.org/10.1016/j.jacadv.2025.102358
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/2149
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publisher's Statement
Publisher's version of record:
https://doi.org/10.1016/j.jacadv.2025.102358