Mechanical Properties, Biodegradation, and Biocompatibility of Porous Mg Alloy Scaffolds for Load Bearing Bone Applications
Document Type
Article
Publication Date
1-1-2024
Abstract
The fabrication, corrosion, mechanical and cell behavior of biodegradable porous Mg-based alloy scaffolds were investigated and are described in this contribution. Using a combination of the casting and computer numerical control methods, a series of porous alloy scaffolds with spherical pore morphology and three different porosity values ranging from 30 to 50%, having pore sizes of about 800 μm were manufactured. Compression tests were used to gauge the porous scaffolds’ mechanical characteristics, and contrast findings with those of cancellous bone tissue. Greater compressive strength (72 MPa) was found for porous alloy scaffolds with 30% porosity than for scaffolds with 50% porosity (21 MPa). The scaffolds with 50% and 30% porosity demonstrated the corrosion rate of 4.3 mm/year and 3.5 mm/year, respectively. Additionally, biocompatibility tests showed that high porosity scaffolds (50%) express higher cell viability (97%) and alkaline phosphatase activity. These findings indicate that open-porous Mg alloy scaffolds could be used as biodegradable implants for bone replacement applications.
Publication Title
Journal of Materials Engineering and Performance
Recommended Citation
Rezaei-Baravati, A.,
Kasiri-Asgarani, M.,
Bakhsheshi-Rad, H.,
Omidi, M.,
Karamian, E.,
Abazari, S.,
Sharif, S.,
Ismail, A.,
&
Drelich, J.
(2024).
Mechanical Properties, Biodegradation, and Biocompatibility of Porous Mg Alloy Scaffolds for Load Bearing Bone Applications.
Journal of Materials Engineering and Performance.
http://doi.org/10.1007/s11665-024-10316-w
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/1241