Aggregation of Β -amyloid fragments
Document Type
Article
Publication Date
1-15-2007
Abstract
The authors study the folding and aggregation of six chains of the Β -amyloid fragment 16-22 using Monte Carlo simulations. While the isolated fragment prefers a helical form at room temperature, in the system of six interacting fragments one observes both parallel and antiparallel Β sheets below a crossover temperature Tx ≈420 K. The antiparallel sheets have lower energy and are therefore more stable. Above the nucleation temperature the aggregate quickly dissolves into widely separated, weakly interacting chains. © 2007 American Institute of Physics.
Publication Title
Journal of Chemical Physics
Recommended Citation
Meinke, J.,
&
Hansmann, U.
(2007).
Aggregation of Β -amyloid fragments.
Journal of Chemical Physics,
126(1).
http://doi.org/10.1063/1.2423013
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8858