Scalable synthetic oligodeoxynucleotide purification with use of a catching by polymerization, washing, and releasing approach
Document Type
Article
Publication Date
8-20-2010
Abstract
Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides. © 2010 American Chemical Society.
Publication Title
Organic Letters
Recommended Citation
Fang, S.,
&
Fueangfung, S.
(2010).
Scalable synthetic oligodeoxynucleotide purification with use of a catching by polymerization, washing, and releasing approach.
Organic Letters,
12(16), 3720-3723.
http://doi.org/10.1021/ol101316g
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/8195