Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups
Document Type
Article
Publication Date
8-5-2016
Abstract
© 2016 American Chemical Society. By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.
Publication Title
Organic Letters
Recommended Citation
Lin, X.,
Chen, J.,
Shahsavari, S.,
Green, N.,
Goyal, D.,
&
Fang, S.
(2016).
Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.
Organic Letters,
18(15), 3870-3873.
http://doi.org/10.1021/acs.orglett.6b01878
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7823