Title

Conformational flexibility of inositol phosphates: Influence of structural characteristics

Document Type

Article

Publication Date

7-1-2002

Abstract

Dynamic NMR and molecular modeling techniques were employed to investigate the influence of structural characteristics on the ring inversion processes of inositol phosphates. The results indicate that inositol phosphates that contain the syn-1,3,5-triaxial trisphosphate arrangement show great proclivity to adopt the sterically hindered conformation. These results suggest that the ability to form chelation cages with counter-ions is a major factor in the ring inversion processes of inositol phosphates. © 2002 Elsevier Science Ltd. All rights reserved.

Publication Title

Tetrahedron Letters

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