dM-Dim for carboxylic acid protection
Document Type
Article
Publication Date
5-2-2018
Abstract
© 2018 Elsevier Ltd The 1,3-dithian-2-yl-methyl (Dim) and its analogous groups including dimethyl-Dim (dM-Dim) can provide a new dimension of orthogonality for carboxylic acid protection. They can be deprotected under nearly neutral oxidative conditions. In this paper, the protection of carboxylic acid with dM-Dim, deprotection of dM-Dim ester with sodium periodate, stability of dM-Dim protected carboxylic acid under acidic and basic conditions, and selective deprotection of dM-Dim protected carboxylic acids in the presence of tertiary butyl and methyl esters are presented.
Publication Title
Tetrahedron Letters
Recommended Citation
Shahsavari, S.,
Wigstrom, T.,
Gooding, J.,
McNamara, C.,
&
Fang, S.
(2018).
dM-Dim for carboxylic acid protection.
Tetrahedron Letters,
59(18), 1763-1766.
http://doi.org/10.1016/j.tetlet.2018.03.076
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7157