Palladium-catalyzed cross-coupling of aryl chlorides with alkenylboronic acids with low E/Z isomerization
Document Type
Article
Publication Date
9-22-2008
Abstract
Using a bulky electron-rich monodentate benzoferrocenyl phosphine as supporting ligand, an efficient protocol for stereoselective palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides with alkenylboronic acids was uncovered. Using this protocol, both trans- and cis-alkenylboronic acids can be coupled with high stereoselectivity giving the corresponding vinylarenes in good to quantitative yields. Electron-poor and -rich aryl chlorides including highly hindered ones are all suitable substrates for the reaction. © 2008 Elsevier Ltd. All rights reserved.
Publication Title
Tetrahedron Letters
Recommended Citation
Thimmaiah, M.,
Zhang, X.,
&
Fang, S.
(2008).
Palladium-catalyzed cross-coupling of aryl chlorides with alkenylboronic acids with low E/Z isomerization.
Tetrahedron Letters,
49(39), 5605-5607.
http://doi.org/10.1016/j.tetlet.2008.07.050
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7153
