Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by < sup> 19 F NMR spectroscopy
Document Type
Article
Publication Date
4-18-2005
Abstract
The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method. © 2005 Elsevier Ltd. All rights reserved.
Publication Title
Tetrahedron Asymmetry
Recommended Citation
Abid, M.,
&
Török, B.
(2005).
Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by < sup> 19 F NMR spectroscopy.
Tetrahedron Asymmetry,
16(8), 1547-1555.
http://doi.org/10.1016/j.tetasy.2005.02.034
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7151
