Beyond Dimerization: A Membrane-dependent Activation Model for Interleukin-4 Receptor-mediated Signalling
Document Type
Article
Publication Date
3-9-2007
Department
Department of Physics
Abstract
Class I cytokine receptors efficiently transfer activation signals from the extracellular space to the cytoplasm and play a dominant role in growth control and differentiation of human tissues. Although a significant body of literature is devoted to this topic, a consistent mechanistic picture for receptor activation in the membrane environment is still missing. Using the interleukin-4 receptor (IL-4R) as an example, we propose that the membrane-proximal stem-loop of the extracellular domains contains pivotal elements of a rotational switch. Interfacial energies of amino acid side-chains contained in the highly conserved WSXWS at the surface of the lipid bilayer suggest a new functional role for this motif. A generic activation mechanism for this receptor class is presented, which may impact the design of a new generation of biophysical assay systems.
Publication Title
Journal of Molecular Biology
Recommended Citation
Weidemann, T.,
Hofinger, S.,
Müller, K.,
&
Auer, M.
(2007).
Beyond Dimerization: A Membrane-dependent Activation Model for Interleukin-4 Receptor-mediated Signalling.
Journal of Molecular Biology,
366(5), 1365-1373.
http://doi.org/10.1016/j.jmb.2006.11.095
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6756
